Lois, Lana, Cat And Chloe

In 1938, Superman introduced Lois Lane.
In 1950, Superboy introduced Lana Lang.
In 1987, a new version of Superman introduced Cat Grant.
In 2001, Smallville introduced Chloe Sullivan, who is:

Lois' cousin;
the only one of these four to appear first on screen.

The Superman myth can still introduce new enduring characters.